现代的纽约圣诞夜，当人们不再嘘寒问暖，五个素昧平生的人将会重新发现圣诞的真谛。杰拉找到勇气走出阴霾，亚提(亚伦阿金)悲剧的往事提醒了麦克珍惜眼前与妮娜(佩内洛普·克鲁兹)的关系，同时，萝丝(苏珊·萨兰登)找到了人生新希望，一段意想不到的友谊点醒了她，没有人在圣诞夜是真正孤独的…… In the Christmas Eve in New York, the lonely divorced publisher Rose Harrison (Susan Sarandon) expects for a miracle to improve the health of her mother, interned in a hospital with Alzheimer. She feels sorry for the patient of the room in front of her mother's and meets his visitor (Robin Williams). Meanwhile, the Latin Nina Vasquez (Penélope Cruz) breaks her engagement with her beloved fiancé Mike (Paul Walker) due to his suffocating jealousy, but misses him. Mike is stalked by the stranger bartender Artie Venzuela (Alan Arkin). The poor Jules (Marcus Thomas) expects to spend the Christmas night in the hospital, where he spent the best Christmas of his life when he was a teenager. The lives of some of these characters cross with others along the night.